The intestine is a complex organ with multiple functions, and containing lots of different cell types. In addition to being the primary site of digestion and nutrient absorption, it also has one of the largest concentrations of immune cells and neuroendocrine cells. Our group has several projects focused on understanding the complex interactions between the cells of the intestine and the trillions of microbes that call our guts home, and how these interactions influence growth, health, and survival.
Improving Health Through The Intestinal Microbiota
Hughes R-A, Ali RA, Mendoza M, Hassan HM, Koci MD. Prebiotic-mediated changes to the microbiome alters host mucosal gene expression: possible approach to control Salmonella in poultry. Front. Vet. Sci., 13 November 2017 https://doi.org/10.3389/fvets.2017.00192
AL Ballou, RA Ali, MA Mendoza, JC Ellis, HM Hassan, WJ Croom, MD Koci. Development of the Chick Microbiome: How Early Exposure Influences Future Microbial Diversity. Frontiers in Veterinary Science 3:2. (2016) DOI: 10.3389/fvets.2016.00002.
R. Qiu, J. Croom, R. A Ali, A. L. Ballou, C. Smith, C. M. Ashwell, H. M. Hassan, C.-C. Chiang, and M. D. Koci. Direct fed microbial supplementation repartitions host energy to the immune system. Journal of Animal Science. 90:1–13, 2012.
J. Croom, M. Chichlowski, M. Froetschel, B. W. McBride, R. Qiu and M. D. Koci. The Effects of Direct-Fed Microbial, Primalac®, or Salinomycin Supplementation on Intestinal Lactate Isomers and Cecal Volatile Fatty Acid Concentrations in Broilers. International Journal of Poultry Science. 8: 128-132, 2009.
M. Chichlowski, J. Croom, B. W. McBride, L. R. Daniel, G. Davis and M. D. Koci. Direct-Fed Microbial and Salinomycin Modulate Whole Body and Intestinal Oxygen Consumption and Intestinal Mucosal Cytokine Production in the Broiler Chick. Poultry Science. 86:1100-1106, 2007.
M. Chichlowski, J. Croom, F. Edens, B. W. McBride, R. Qiu, C. C. Chiang, L. R. Daniel, G. W. Havenstein and M. D. Koci. Microarchitecture and Spatial Relationship Between Bacteria and Ileal, Cecal and Colonic Epithelium in Chicks Fed a Direct-Fed Microbial and Salinomycin. Poultry Science. 86:1121-1132, 2007.